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Stokvis-Talma syndrome

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A historic term for acquired methemoglobinaemia. It is an association of cyanosis, severe enteritis, abdominal pain, constipation or diarrhoea, headache, syncope, dizziness, anaemia, and clubbing of the fingers due to methemoglobinaemia. It occurs in the presence of sulfhaemoglobin produced by substances entering the body through the gastrointestinal tract. The eponym is obsolete, and some authors dispute whether this is an entity. A congenital variant is known as Gibson's syndrome.


  • B. J. Stokvis:
    Bijdrage tot de casuïstiek der autotoxische enterogene cyanosen (methaemaoglobinaemia?) et enteritis parasitaria.
    Nederlandsch Tijdschrift voor Geneeskunde, Amsterdam, 1902, 38: 678-693.
  • S. Talma:
    Intraglobuläre Methämoglobinämie beim Menschen.
    Berliner klinische Wochenschrift, 1902, 39: 865-867.
  • A. Hijmans Van den Bergh:
    Enterogene Cyanose.
    Deutsches Archiv für klinische Medizin, Leipzig, 1905; 83: 86-106.

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