- A dictionary of medical eponyms

Hayem-Widal disease (Georges Fernand Isidore Widal)

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A now obsolete term for a haematological disorder clinically characterised by decreased red blood count, spherocytosis, icterus, and splenomegaly. The erythrocytes are formed normally but are destroyed prematurely as a result of haemolytic processes. Slightly more prevalent in females; onset at all ages. Extremely variable clinical features. The term Hayem-Widal is now generally being replaced by «acquired haemolytic anaemia.»

See also:
Dyke-Young syndrome - a chronic macrocytic type of anaemia, under Sidney Campbell Dyke, English pathologist, born 1886.

Lederer-Brill disease - acute febrile hemolytic anaemia, under Max Lederer, American pathologist, 1885-1952.

Loutit’s syndrome - haemolytic jaundice, under John Freeman Loutit, British physician, born 1910.


  • G. Hayem:
    Sur une variété particulière d’ictère chronique. Ictère infectieux chronique splénomégalique.
    La presse médicale, Paris, 1898, 6: 121-125. Sur une variété particulière d’ictère chronique splénomégalique.
    J Méd intern., 1898, 2: 116-118.
  • F. Widal, P. Ravaut:
    Ictère chronique acholurique congénital chez un homme de vingt-neuf ans.
    Bulletins et memoires de la Société medicale des hôpitaux de Paris, 1902, 19: 984-991.
  • F. Widal, P. Abrami:
    Ictère hémolytique non congénitaux avec anémie. Recherches de la résistance globulaire par la procédé de hématises déplasmatisées.
    La presse médicale, Paris, 1907, 15: 749. divers d’ictère hémolytiques non congénitaux, avec anémie; la recherche de la résistance glubulaire par le procédé des hématies déplasmatisées.
    Bulletins et memoires de la Société medicale des hôpitaux de Paris, 1907, 24: 1127-1169.
  • B. Dreyfus, J. Dausset, G. Widal:
    Étude clinique et hématologique de douze cas d’anémie hémolytique acquise avec anti corps.
    Revue d'hématologie, 1951, 6: 349.
  • J. V. Dacie, P. L. Mollison, N. Richardson, et al:
    Atypical congenital haemolytic anaemias.
    Clinical Immunology and Allergy. London, Philadelphia, Baillière Tindall, 1987. Volume 1, p 251.

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