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Nathan Edwin Brill
American internist, born January 13, 1860, New York;
died December 13, 1925, New York City.
Associated eponyms:
Brill's disease
An infectious rickettsial disease transmitted by the human louse or a flea and characterized by fever, a transient rash, and falling blood pressure.
Brill-Symmers disease
A lymphoma characterized by the combined proliferation of lymphoblasts and reticulum cells within lymphoid follicles, resulting in an increase in the number and size of germinal follicles.
Hayem-Widal disease (Georges Fernand Isidore Widal)
A now obsolete term for a haematological disorder clinically characterised by decreased red blood count, spherocytosis, icterus, and splenomegaly.
Lederer's anaemia
An acute, transient type of Lederer-Brill disease. A form of acute haemolytic anaemia of infectious origin, with rapid onset and recovery in children.
Lederer-Brill disease
Obsolete term for an autoimmune haemolytic aneamia with extremely variable clinical features.
Biography:
Nathan Edwin Brill attended the New York University College, receiving his medical doctorate there in 1880. He was an intern at the Bellevue Hospital from 1879 to 1881. In 1882 he was appointed physician at the Mount Sinai Hospital, becoming professor at the College of Physicians and surgeons. He distinguished himself in particular as an outstanding diagnostician.
Brill translated Georg Klemperer’s (1865-1946) book Clinical Diagnosis in 1898 and discovered a previously unrecognised form of typhus which is called recurrent typhus - Brill-Zinsser’s disease - in immigrants from Eastern Europe without body lice. The disease seems to be a recurrence of a latent infection following a primary lice/tick-born typhus. Clinically it resembles mild typhus, but may also occur after the first infection.
Bibliography:
- G. Klemperer:
Grundriss der klinischen Diagnostik.
Berlin, 1890; 26th edition, 1931.
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