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Del Castillo's disease

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A form of hypergonadotrophic hypogonadism in male patients characterized by seminiferous tubules lined with Sertoli cells, Leydig cells also being present, but germinal cells are absent from the germinal epithelium.

The affected males are sterile and usually have small testes, but are otherwise normally developed with all secondary sexual characteristics, normal size phallus, scrotum, pubic hair, libido and erection Etiology is uncertain, in som rare cases X-linked transmission seems probable.


  • E. B. Del Castillo, A. Trabucco, F. A. de la Balze:
    Syndrome produced by absence of germinal epithelium without impairment of Sertoli or Leydig cells.
    Journal of Clinical Endocrinology, Baltimore, 1947, 7: 493-502.
    Based on observations of five patients.

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