- A dictionary of medical eponyms

Weber's paralysis

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Partial or complete oculomotor paralysis and contralateral hemiplegia due to lesions of the nucleus of the third cranial nerve and its ventral fibres crossing the midbrain and the pyramidal tract. The most common type of lesion causing haemorrhage or thrombosis, although a neoplasm of the pituitary region may, if it extends dorsally, result in this syndrome.

Weber: Infarction or a tumour of the brainstem produces paralysis of the third cranial nerve on the same side and hemiparesis on the opposite side.

The disease picture was first described in 1838 by August Nikolaus Gendrin (1796-1890). The term «Weber’s syndrome» was introduced by Joseph Grasset (1849-1918).


  • A. M. Gubler:
    De l'hémiplégie alterne envisagée comme signe de lésion de la protubérance annulaire et comme preuve de la décussation des nerfs faciaux.
    Gazette hebdomadaire de médecine et de chirurgie, Paris, 1856, 3: 749-754, 789-792, 811-816.
    English translation in Wolf, The Classical Brain Stem Syndromes. Springfield, Thomas, 1971.
  • H. D. Weber:
    A contribution to the pathology of the crura cerebri.
    Medico-Chirurgical Transactions, London, 1863, 46: 121-139.
  • E. V. von Leyden:
    Klinik der Rückenmarkskrankheiten.
    Berlin, Hirschwald, 1876. Volume 2, page 64.
  • J. Grasset:
    Un type spécial de paralysie alterne motrice etc.
    Revue neurologique, Paris, 1900, 8: 586.

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