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Voorhoeve's disease

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A syndrome of osteopathia striata and cranial sclerosis affecting both sexes. It is a peculiar form of osteosclerosis in which parallel lines of sclerosis are radiographically evident in the pelvis and tubular bones. The striations are seen along the axes of the long bones extending from the metaphyses and as and fan-like striations of the iliac bones, with areas of rarefaction interspersed between dense striations. From mild cranial enlargements to abnormalities (with Pierre Robin syndrome). Possibly associated: hearing defects, scoliosis, spondyloisthesis. There are minimal clinical symptoms. Inheritance is autosomal dominant. The connection with cranial sclerosis was recognised by R. L. Hunt in 1953, who introduced the eponymic term Voorhoeve's.


  • N. Voorhoeve:
    L’image radiologique non encore décrite d’une anomalie du squélette. Ses rapports avec la dyschondroplasie et l'osteopathia condensans disseminata.
    Acta Radiologica, Stockholm, 1924, 3: 407-427.
  • H. A. T. Fairbank:
    A case of unilateral affection of the skeleton of unknown origin.
    The British Journal of Surgery, London, 1925, 12: 594-597. Osteopathia striata.
    Proceedings of the Royal Society of Medicine, 1935, 28: 1616.
    The Journal of Bone and Joint Surgery, London, 1950, 32: 117-125. An Atlas of General Affections of the Skeleton.
    Edinburgh, Livingstone, 1951.
    Baltimore, Williams & Wilkins, 1951. Pages 181-183.
  • R. L. Hurt:
    Osteopathia striata – Voorhoeve's disease.
    The Journal of Bone and Joint Surgery, London, 35: 89-96.
  • F. Horan, P. Beighton:
    Osteopathia striata with cranial sclerosis. An autosomal dominant entity.
    Clinical Genetics, Copenhagen, 1978, 13: 201-206.

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