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Filatov's disease

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An acute infectious disease caused by the Epstein-Barr virus. It is characterized by a triad of fever, lymphadenopathy, and pharyngitis. Common symptoms are mild throat inflammation, malaise, anorexia, and chills. Both sexes equally affected. Onset at all ages, but highest frequency in 20 to 25 year bracket. Epidemics in young communities.

Infectious mononucleosis was first described by Filatov under the name of "idiopathic denitis". The term “infectious mononucleosis” was first used by Sprunt and Evans in 1920.


  • N. Filatov:
    Lektsii ob ostrikh infeksionnîkh boleznyakh u dietei.
    2 volumes. Moskva, A. Lang, 1887.
    [Lectures on acute infectious diseases in children.]
  • E. Pfeiffer:
    Drüsenfieber. Jahrbuch für Kinderheilkunde und physische Erziehung, Wien, 1889, 29: 257-264.
    Pfeiffer is by some accredited with the original description of infectious mononucleosis, ascribed to Filatov. Pfeiffer's paper is a most comprehensive discussion of the clinical aspects of the disease.
  • W. Türk:
    Vorlesungen über klinische Haematologie.
    Volume II. Vienna, 1904.
  • T. P. V. Sprunt, Frank Alexander Evans (1889-1956):
    Mononuclear leukocytosis in reaction to acute infection (infectious mononucleosis).
    Bulletin of the Johns Hopkins Hospital, Baltimore, 1920, 31: 410-417.
We thank Patrick Jucker-Kupper, Switzerland, for information submitted.

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