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Millard-Gubler syndrome

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A syndrome of unilateral softening of the brain tissue arising from obstruction of the blood vessels of the pons, involving the sixth and seventh cranial nerves and fibres of the corticospinal tract, and associated with paralysis of the abducens and facial nerves and contralateral hemiplegia of the extremities. The muscles of the ipsilateral side of the face are paralysed, and the ophthalmologic characteristics are diplopia, internal strabismus, and loss of power to rotate eye outward.

If there is also paralysis of inward movement of the eye in attempting to look toward the side of the lesion, the condition is known as Foville syndrome. The disturbance was described by Millard in 1855, Gubler in 1856.


  • A. M. Gubler:
    De l'hémiplégie alterne envisagée comme signe de lésion de la protubérance annulaire et comme preuve de la décussation des nerfs faciaux.
    Gazette hebdomadaire de médecine et de chirurgie, Paris, 1856; 3: 749-754, 789-792, 811-816.
    English translation in Wolf, The classical brain stem syndromes. Springfield, Thomas, 1971.

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