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Weber-Cockayne syndrome

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A form of epidermolysis bullosa. Consists of recurrent, noninflammatory bullous eruptions mainly on the feet, less prominently on the hands. Onset after mechanically induced trauma (blisters) in early childhood, but also in adult age, especially in warm season. Both sexes affected. Sharp pain when bullae rupture. Heals without residual scarring or other changes, such as thickening of the skin. They are occasionally associated with hyperhidrosis. Autosomal dominant or recessive inheritance. Warm weather, irritation, pressure, and moisture appear to be factors in the production of the syndrome. Probably a mildly pronounced form of the generalised Epidermolysis bullosa simplex Koebner.

Aetiology unknown. Autosomal dominant inheritance. Familial cases have been reported.

It was first reported by G. T. Elliott in 1895, and then described by L. B. Cane in British Medical Journal in 1909, Frederick Parkes Weber in 1926, and Edward Alfred Cockayne in 1938.


  • G. T. Elliot:
    Two cases of epidermolysis bullosa.
    Journal of Cutaneous and Genitourinary Diseases, Chicago, 1895, 13: 10-18.
  • F. P. Weber:
    Recurrent bullous eruption of the feet in a child.
    Proceedings of the Royal Society of Medicine, London, 1926, 19: 72.
  • E. A. Cockayne:
    Recurrent bullous eruption of the feet.
    British Journal of Dermatology and Syphilis, Oxford, 1938, 50: 358-362.
  • A. Touraine:
    L’hérédité en medicine.Paris, Masson, 1955.

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