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Clarke-Hadfield syndrome

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Obsolete entity of infantilism caused by congenital pancreatic insufficiency (deficient secretion of pancreatic enzymes). Characterised by a triad of cystic fibrosis of the pancreas (mucoviscidosis), celiac disease, and vitamin A deficiency. A child suffering from this syndrome has poor muscles, is lacking of subcutaneous fat, underweight and fails to grow. Both sexes affected; onset at early age. Etiology unknown.

See also Landsteiner-Fanconi-Andersen syndrome, under Karl Landsteiner, Austrian-American immunologist and pathologist, 1868-1943.


  • C. Clarke, G. Hadfield:
    Congenital pancreatic disease with infantilism.
    Quarterly Journal of Medicine, Oxford, 1923-1924, 17: 358-364.
  • G. Fanconi, E. Uehlinger, C. Knauer:
    Das Coeliakiesyndrom bei angeborener zystischer Pankreasfibromatose und Bronchiektasien.
    Wiener medizinische Wochenschrift, 1936, 86: 753-756.
  • D. H. Andersen:
    Cystic fibrosis of the pancreas and its relation to celiac disease. A clinical and pathological study.
    American Journal of Diseases of Children, Chicago, 1938, 56: 344-399.
  • D. H. Andersen:
    Studies on glycogen disease with a report of a case in which the glycogen was abnormal.
    In V. A. Najjar: Carbohydrate Metabolism, pp 28-42. Johns Hopkins University Press, 1952.

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