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Putnam-Dana syndrome
Also known as:
Dana’s syndrome
Dana-Putnam syndrome
Lichtheim’s syndrome
Putnam's disease
Associated persons:
Charles Loomis Dana
Ludwig Lichtheim
James Jackson Putnam
Description:
A neurological disease with great variability of symptoms, characterized by degenerative changes in the white matter of the spinal cord associated with pernicious anaemia. Onset is usually insidious with weakness, fatigue, and dyspnoea or exertion. Other symptoms may include paralysis of the legs and arms, with tremor present when there is increase in muscle tone (static tremor), and in movement (kinetic or intentional); myalgia, oedema of the feet and ankles, numbness and tingling in the distal portions of the extremities, glossitis, headache, malaise, and peculiar gait. Early and recurrent mental disorders with hallucinations or a type of dementia paralytica have been seen in patients when the onset of the syndrome was sudden.
Condition widely disseminated, but more common in blond Nordic people. Both sexes affected. Average onset at 50 years of age and later in women than men. Autosomal dominant inheritance.
Bibliography:
- J. J. Putnam:
A group of cases of system sclerosis of the spinal cord, associated with diffuse collateral degeneration; occurring in enfeebled persons past middle life, and epecially in women; studied with particular reference to etiology.
Journal of Nervous and Mental Disease, Baltimore, 1891, 18: 69-110.
- C. L. Dana:
The degenerative diseases of the spinal cord, with the description of a new type.
Journal of Nervous and Mental Disease, Baltimore, 1891, 18: 205-216.
- L. Lichtheim:
Zur Kenntnis der perniciösen Anämie.
Verhandlungen des Deutschen Kongress für innere Medizin, 1889, 6: 84-96. 42: 1887.
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