- A dictionary of medical eponyms

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A blood coagulation disorder due to factor XII deficiency. Factor XII is a plasma protein which on activation by surface contact sets off chain reactions activating the clotting of blood, kinin, fibrinolytic and complement pathways. In a deficiency of Hagemann’s factor there is a sustained coagulation time, but rarely haemorrhagic symptoms. Asymptomatic with few minor exceptions. Laboratory curiosity. Inheritance is autosomal recessive. Families with autosomal dominant condition found.


Oscar D. Ratnoff and Joan E. Colopy:
•  A familial hemorrhagic trait associated with a deficiency of a clot-promoting
   fraction of plasma.
   Journal of clinical investigation, New York, 1955; 3: 602-613.

Oscar D. Ratnoff, R. J. Busse and R. P. Sheon:
•  The demise of John Hageman.
    New England Journal of Medicine, Boston, 1979: 260-261.

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An eponym is a word derived from the name of a person, whether real or fictional. A medical eponym is thus any word related to medicine, whose name is derived from a person.

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