- A dictionary of medical eponyms

Hageman's factor

Synonyms

Also known as Hageman deficiency factor, Hageman trait, Factor XII deficiency.

Related people

A blood coagulation disorder due to factor XII deficiency.

Description

A blood coagulation disorder due to factor XII deficiency. Factor XII is a plasma protein which on activation by surface contact sets off chain reactions activating the clotting of blood, kinin, fibrinolytic and complement pathways. In a deficiency of Hagemann’s factor there is a sustained coagulation time, but rarely haemorrhagic symptoms. Asymptomatic with few minor exceptions. Laboratory curiosity. Inheritance is autosomal recessive. Families with autosomal dominant condition found.

Bibliography

Oscar D. Ratnoff and Joan E. Colopy:
•  A familial hemorrhagic trait associated with a deficiency of a clot-promoting
   fraction of plasma.
   Journal of clinical investigation, New York, 1955; 3: 602-613.

Oscar D. Ratnoff, R. J. Busse and R. P. Sheon:
•  The demise of John Hageman.
    New England Journal of Medicine, Boston, 1979: 260-261.

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