American railroad brakeman, born 1918; died 1968.
Biography of John Hageman
The condition is named for the person
in whom it was first discovered, John
Hageman, a railroad brakeman. In 1955, when he was 37 years old, a routine
preoperative blood sample showed prolonged clotting time in test tubes, even
though he had no haemorrhagic symptoms.
Neither he nor his family had had a bleeding tendency, and he had not bled
excessively after tonsillectomy, dental
extractions or injuries.
Hageman was then examined by Dr. Oscar Ratnoff who found that Mr. Hageman lacked a previously unidentified clotting factor. Dr. Ratnoff later found that the Hageman factor deficiency is an autosomal recessive
disorder, when examining several related people who had the deficiency.
Hageman was 52 yars of age and working as a brakeman on the railways and fell from the ladder of the carriage of a moving train on 11 March 1968. He was taken to hospital, where he spent a week before he suddenly
died of pulmonary embolism.
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