Kashin-Bek disease

A slowly progressive, degenerative osteoarthrosis of the spine and joints of the extremities in children and adolescents in northern Siberia, northern China, and Northern Korea. It is believed to be a form of mycotoxicosis caused by eating grain contaminated with the fungus Fusaria sporotrichiella. The alternative name is Urov diseae, because it was first recognised among settlers near the Urov River, Transbaikal. Endemic in Korea, northern China, and Siberia. In China it affects between 1 and 3 million people and is considered a health problem

We thank Richard Avery for information submitted.

• N. I. Kashin:
  [The description of the endemic and other disease, prevailing in the Urov river area.]
  The records of physico-medical scientific society attached to the Moscow University, 1859.
• N. I. Kashin:
  Nachrichten über die Verbreitung des kropfes und Kretinismus in den Grenzen des russischen Kaiserreiches.
  Moskovskaya meditsinskaya Gazeta, 1861, 5: 39-51. .
• E. V. Bek:
  K voprosu ob obezabrazhivaiuschchem endemicheskom osteorartritu (osteoarthritis deformans endemica) v Zabaikal'skoi oblasti.
  [To the problem of deforming endemic osteoarthritis in the Baikal area]
  Russkii Vrach [Russian Physician], 1906, 5: 74-75.
• Zur Frage der Osteoarthritis deformans endemica im Transbaikalgebiet.
  Mil Med Akad Diss, 1906; quoted by Goldstein and Nikiforov.
• D. Goldstein, P. Nikiforov:
  Über die sogenannte Kaschin-Beck’ Krankheit.
  Fortschritte auf dem Gebiete der Röntgenstrahlen, Stuttgart, 1931, 43: 321-336.
• Sergio I. Magalini, Sabina C. Magalini, Giovanni de Francisi:
  Dictionary of Medical Syndromes. J. B. Lippincott Company, Philadelphia. 1990.
• Stanley Jablonski:
  Jablonski’s Dictionary of Syndromes & Eponymic diseases.
  Krieger Publishing Company, Malabar, Florida, 1991.
• Taro Yamanaka:
  Studien über die Kaschin-Becksche Krankheit. 3. Ueber die Blut-Wasserstoffionenkonzentration und ihre Pufferwirkung bei der Kaschin-Beckschen Krankheit. 1939.
  Taro Yamanaka was director of the Univesity medical Clinic Muknen, Mandschoukuo.
• Bernfried Leiber, editor:
  Die klinischen Syndrome. Syndrome, Sequenzen und Symptomenkomplexe.
  Urban & Schwarzenberg, München-Wien-Baltimore, 1990. 8th edition, München 1997.
• E. Allander:
  Kashin-Beck disease. An analysis of research and public health activities based on a bibliography 1849-1992.
  Scandinavian Journal of Rheumatology, 1994, 23 (Supplement): 1-36.