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Heberden's disease
Also known as:
Heberden’s syndrome
Master’s disease
Asma di Elsner
Elsner's asthma
Elsner’s disease
Rougnon’s disease
Rougnon de Magny’s disease
Associated persons:
Christoph Friedrich Elsner
William Heberden
Nicolas François Rougnon de Magny
Description:
A clinical syndrome of chest pain caused by a relative oxygen deficiency in the heart muscle. It occurs most commonly in the presence of arteriosclerotic coronary artery disease, but also in ventricular hypertrophy, left ventricle outflow obstruction, aortic regurgitation, cradiomyopathy, and other pathological conditions of the heart. The symtpoms include a sudden mild, severe or excruciating precordial dull pain, and tightness, accompanied by anxiety. The pain radiates to the left shoulder, arm, and hand. Short duration (usually less than 3 minutes). The condition is precipitated by emotion, effort, cold exposure, heavy meal. Described first by Heberden as angina pectoris in 1785. An authentic case of angina pectoris is recorded by Giovanni Battista Morgagni (1682-1771), who observed it in 1707.
Bibliography:
- G. Lancisi:
De subitaneis Mortibus. Rome, 1707.
- G. B. Morgagni:
De sedibus et causis morborum per anatomen indagatis libri quinque.
2 volumes. Venice, 1761. Volume 1, page 282.
(On the Seats and causes of Diseases Investigated by Anatomy)
- Nicolas François Rougnon de Magny (1727-1799)
Lettre de M. Rougnon à M. Lorry, touchant les causes de la mort de feu Monsieur Charles, ancien capitaine de cavalerie, arrivé a Besançon le 23 février 1768. Besançon, J. F. Charmet, 1768.
William Osler (1849-1919), Thomas Clifford Allbutt (1836-1925) and several other authorities believed this to be the description of and authentic case of angina, thus preceding Heberden’s classic account. Other eminent authorities consider the patient to hav suffered from pulmonary emphysema. This little book of 55 pages is extremely rare; the whereabout of only 2 copies is known.
- W. Heberden:
Some account of a disorder of the breast.
Medical Transactions, published by the Royal College of Physicians of London, 1772, 2: 59-67.
- C. F. Elsner:
Abhandlung über die Brustbräune. Königsberg, 1778.
- Hans Kohn:
Zur Geschichte d. Angina pectoris: Heberden oder Rougnon?
Zeitschrift für klinische Medizin, Berlin, 1927, 106: 1-20.
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