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Achard-Thiers syndrome

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A disorder mainly affecting postmenopausal women, marked by diabetes mellitus and hirsutims, deep masculine voice, facial hypertrichosis, obesity, hypertrophy of the clitoris, and hypoplasia or adenoma of the adrenal cortex. Possibly increased frequency of cancer uteri associated with tumor or hyperplasia of the adrenal cortex. Amenorrhea, hypertension, and osteoporosis are often present. Pathological findings include liver cirrhosis, atrophy or sclerosis of the ovaries, and an increase in the size of the islands of Langerhans. Combined features of adrogenital syndrome and Cushing’s syndrome.


  • E. C. Achard, J. Thiers:
    Le virilisme pilaire et son association à l'insuffisance glycotique (diabète des femmes à barbe).
    Bulletin de l’Académie Nationale de Médecine, Paris, 1921, 3 sér., 86: 51-56.

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