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Tolosa-Hunt syndrome (William Edward Hunt)

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A syndrome characterized by recurrent, sharp unilateral retro-orbital pain with extraocular palsies, usually involving the third, fourth, fifth, and sixth cranial nerves. Other features include proptosis and sensory loss over the forehead, sluggish pupil reaction to light, and diminished corneal sensitivity with blurred vision up to complete blindness. It is attributed to a granulomatous infiltration or an invasive tumour at the apex of the orbit or in the region of the cavernous sinus. Males and females equally affected. The disease usually lasts several months to several years. Onset usually in the fifth decade.


  • E. Tolosa:
    Periarteritic lesions of carotid siphon with clinical features of a carotid infraclinoidal aneurysm.
    Journal of Neurology, Neurosurgery and Psychiatry, London, 1954, 17: 300-302.
  • E. Tolosa, P. Fuenmayor, J. Llovet:
    Syndrome du sinus caverneux. Considérations sur ses formes bénignes et spontanement régressives.
    Revue d'oto-neuro-ophthalmologie, Paris, 1961, 33: 365-368.
  • W. E. Hunt, John N. Meagher, Harry E. LeFever, W. Zeman:
    Painful ophthalmoplegia. Its relation to indolent inflammation of the cavernous sinus. Neurology, 1961, 11: 56-62.

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