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Guerreiro-Machado reaction

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A complement-fixation test for infection with Trypanosoma cruzi - Chagas’ disease. An indirect method of laboratorial diagnosis of American trypanosomiasis. When positive, this test remains so throughout life, thus being a good indicator of previous infection.

The reaction applies the so-called complement fixation reaction, developed in 1906 to diagnose syphilis. Before that, Jules Jean Baptiste Vincent Bordet (1870-1961) and Octave Gengou (1875-1957) had developed a complement-fixation reaction in 1901. The reaction for syphilis was developed in 1906 by August Paul von Wassermann (1866-1925), Albert Ludwig Sigesmund Neisser (1855-1916) and Carl Bruck (1879-1944).

We thank Andre Trombeta for information submitted.


  • J. J. B. V. Bordet and O. Gangou:
    Sur l’existence de substances sensibilisatrices dans la plupart des sérums antimicrobiens.
    Annales de l’Institut Pasteur, Paris, 1901, 15: 289-302.
  • A. P. von Wassermann, A. Neisser, C. Bruck:
    Eine serodiagnostische Reaktion bei Syphilis.
    Deutsche medicinische Wochenschrift, Berlin, 1906, 32: 745-746.
  • C. Guerreiro and A. Machado:
    Da reação de Bordet e Gengou na moléstia de Carlos Chagas como elemento diagnóstico (nota preliminar).
    Brasil Médico, Rio de Janeiro, June 1913, 27 (23): 225.
  • J. O. Almeida, T. A. Cunha:
    Estudos sobre a reacao de Guerreiro-Machado. Efeitos da inativacao do soro chagasico na fixacao do complemento com antigeno de Trypanosoma cruzi. / Study on Guerreiro-Machado reaction. Inactivation effect of Chagas's serum in complement fixation with Trypanosoma cruzi antigen.
    Memorias do Istituto Oswaldo Cruz, Rio de Janeiro 1981, 76 (3): 269-277.
  • J. O. Almeida:
    Estudos sobre a reacao de Guerreiro Machado. Analise cromatografica de antigenos de Trypanosoma cruzi. / Guerreiro Machado reaction.Chromatographic analysis of Trypanosoma cruzi antigens.
    Memorias do Istituto Oswaldo Cruz, Rio de Janeiro, 1984, 79 (3): 363-367.

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