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Guerreiro-Machado reaction
Also known as:
Machado-Guerreiro test
Machado-Guerreiro reaction
Associated persons:
César Guerreiro
Astrogildo Machado
Description:
A complement-fixation test for infection with Trypanosoma cruzi - Chagas’ disease. An indirect method of laboratorial diagnosis of American trypanosomiasis. When positive, this test remains so throughout life, thus being a good indicator of previous infection.
The reaction applies the so-called complement fixation reaction, developed in 1906 to diagnose syphilis. Before that, Jules Jean Baptiste Vincent Bordet (1870-1961) and Octave Gengou (1875-1957) had developed a complement-fixation reaction in 1901. The reaction for syphilis was developed in 1906 by August Paul von Wassermann (1866-1925), Albert Ludwig Sigesmund Neisser (1855-1916) and Carl Bruck (1879-1944).
We thank Andre Trombeta for information submitted.
Bibliography:
- J. J. B. V. Bordet and O. Gangou:
Sur l’existence de substances sensibilisatrices dans la plupart des sérums antimicrobiens.
Annales de l’Institut Pasteur, Paris, 1901, 15: 289-302.
- A. P. von Wassermann, A. Neisser, C. Bruck:
Eine serodiagnostische Reaktion bei Syphilis.
Deutsche medicinische Wochenschrift, Berlin, 1906, 32: 745-746.
- C. Guerreiro and A. Machado:
Da reação de Bordet e Gengou na moléstia de Carlos Chagas como elemento diagnóstico (nota preliminar).
Brasil Médico, Rio de Janeiro, June 1913, 27 (23): 225.
- J. O. Almeida, T. A. Cunha:
Estudos sobre a reacao de Guerreiro-Machado. Efeitos da inativacao do soro chagasico na fixacao do complemento com antigeno de Trypanosoma cruzi. / Study on Guerreiro-Machado reaction. Inactivation effect of Chagas's serum in complement fixation with Trypanosoma cruzi antigen.
Memorias do Istituto Oswaldo Cruz, Rio de Janeiro 1981, 76 (3): 269-277.
- J. O. Almeida:
Estudos sobre a reacao de Guerreiro Machado. Analise cromatografica de antigenos de Trypanosoma cruzi. / Guerreiro Machado reaction.Chromatographic analysis of Trypanosoma cruzi antigens.
Memorias do Istituto Oswaldo Cruz, Rio de Janeiro, 1984, 79 (3): 363-367.
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