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Strøm-Zollinger-Ellison syndrome

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This condition comprises a clinical triad of 1) hypesecretion of gastrin, 2) multiple, atypically located, often recurrent peptic ulcers, and 3) a noninsulin producing islet cell tumor of the pancreas. About 60 % of the tumors are malignant. Males affected slightly more frequently than females. Inheritance is autosomal dominant. When associated with familial multiple endocrine adenomatosis, the syndrome is known as the multiple endocrine neoplasia I syndrome.

The term Zollinger-Ellison syndrome is the more common. It was proposed in Gastroenterology in 1956 by B. Eiseman and R. M. Maynard.

We thank Dr. Ugo Grossi for information submitted.


  • R. Strøm:
    A case of peptic ulcer and insuloma.
    Acta Chirurgica Scandinavica, Stockholm, 1952-1953, 104: 252-260.
  • R. M. Zollinger, E. H. Ellison
    Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Annals of Surgery, Philadelphia, 1955, 142: 709-728.
  • B. Eiseman and R. M. Maynard:
    A non-insulin producing islet cell adenoma associated with progressive peptic ulceration. Gastroenterology, 1956, 31: 296.
  • E. H. Ellison, S. D. Wilson:
    The Zollinger-Ellison syndrome : re-appraisal and evaluation of 260 registered cases.
    Annals of Surgery, Philadelphia, 1964, 160: 512-30.
  • E. H. Ellison, S. D. Wilson:
    The Zollinger-Ellison syndrome updated.
    Surgical Clinics of North America, Philadelphia, 1967, 47: 1115-1124.
  • R. M. Zollinger:
    Islet cell tumor and the alimentary tract.
    The American Journal of Roentgenology, 1976, 126 (5): 933-940.
  • R. M. Zollinger:
    L'histoire du syndrome de Zollinger-Ellison.
    Annales de gastroenterologie et d'hépatologie, Paris, 1991, 27, 223-226.
  • S. D. Wilson, E. H. Ellison:
    Total gastrectomy in children with Zollinger-Ellison syndrome.
    Surgery, 1965, 91: 165-173.
  • S. D. Wilson:
    Zollinger-Ellison syndrome in children: a 25-year follow-up.
    Surgery, St. Louis, October 1991, 110 (4): 696-702.

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