The pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. The cause of the pattern of Blaschko lines is unknown; they do not follow nerves, vessels, or lymphatics. In 1901, on the occasion of the 7th Congress of the German Dermatological Society held in Breslau, Blaschko presented his observations on various linear dermatoses. He pointed out that the lines described by these conditions did not only not correspond to any known anatomical basis, but were remarkably consistent both from patient to patient and even from one disease to another. Blaschko proposed an embryonic origin for these lines, but did not elaborate. The lines may represent a clinical expression of a genetically programmed clone of altered cells, perhaps first expressed during embryogenesis
- A. Blaschko:
Die Neven-verteilung in der Haut in ihrer Beziehung zu den Erkrankungen der Haut.
Beilage zu den Verhandlungen der Deutschen Dermatologischen Gesellschaft VII Congress, Breslau, 1901.
- R. Jackson:
The lines of Blaschko: a review and reconsideration: Observations of the cause of certain unusual linear conditions of the skin.
The British Journal of Dermatology, October 1976, 95(4): 349-360.