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Lhermitte-McAlpine syndrome

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A combined pyramidal and extrapyramidal tract syndrome in middle-aged and elderly persons. It is characterised by Parkinsonian rigidity, slowness of movement, loss of associated movements, and a choreiform type of muscular activity of the face, larynx, and pharynx. Other features include mental deterioration with apathy, hallucinations, negativism, delirium, and confusion. It is arteriosclerotic in origin.


  • J. Lhermitte, D. McAlpine:
    A clinical and pathological résumé of combined disease of the pyramidal and extrapyramidal systems, with special reference to a new syndrome.
    Brain, Oxford, 1926, 49: 157-181.

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