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Cabot-Locke murmur

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An early diastolic murmur like that of aortic insufficiency, heard best at the left lower central border in severe anaemia.

Description

An early diastolic murmur like that of aortic insufficiency, heard best at the left lower central border in severe anaemia.

We thank John Paraskos for submitting this comment:

As a cardiologist, while I have never heard of the "Cabot-Locke" murmur of severe anemia, I presume it to be a high flow state in the left main coronary artery causing a coronary bruit. Since left coronary artery flow is almost entirely diastolic, and the left anterior descending artery is just below the left sternal border, it would be a diastolic murmur mimicking aortic regurgitation. It is similar to the "Dock murmur" which is a coronary bruit due to coronary stenosis.

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