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Lederer-Brill disease

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Obsolete term for an autoimmune haemolytic aneamia with extremely variable clinical features. A disturbance usually occurring in children with a recent history of infection. The anaemia is associated with fever, lethargy, abdominal pain, nausea, and vomiting. Massive haemolysis is indicated by anaemia, jaundice, and haemoglobinuria. Spherocytosis and splenomegaly are frequently associated. Slightly more prevalent in females.

See also:
Dyke-Young syndrome - a chronic macrocytic type, under Sidney Campbell Dyke, English pathologist, born 1886.

Hayem-Widal syndrome - acholuric haemolytic icterus with splenomegaly, under Georges Hayem, French physician and haematologist, 1841-1933.

Loutit’s syndrome - haemolytic jaundice, under John Freeman Loutit, British physician, born 1910.


  • M. Lederer:
    A form of acute hemolytic anemia probably of infectious origin.
    The American Journal of the Medical Sciences, 1925; 170 (4): 500-501.

  • S. C. Dyke, F. Young:
    Macrocytic hemolytic anemia associated with increased red cell fragility.
    The Lancet, London, 1938, II: 817-821.
  • B. Dreyfus, J. Dausset, G. Vidal:
    Étude clinique et hématologique de douze cas d’anémie hémolytique acquise avec anti corps.
    Revue d'hématologie, 1951, 6: 349.

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