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Lederer-Brill disease
Also known as:
Dreyfus-Dausset-Widal syndrome
Dyke-Young syndrome
Hayem-Widal-Loutit syndrome
Lederer’s disease
Associated persons:
Nathan Edwin Brill
Jean Dausset
B. Dreyfus
Georges Hayem
Max Lederer
John Freeman Loutit
Georges Fernand Isidore Widal
Description:
Obsolete term for an autoimmune haemolytic aneamia with extremely variable clinical features. A disturbance usually occurring in children with a recent history of infection. The anaemia is associated with fever, lethargy, abdominal pain, nausea, and vomiting. Massive haemolysis is indicated by anaemia, jaundice, and haemoglobinuria. Spherocytosis and splenomegaly are frequently associated. Slightly more prevalent in females.
See also:
Dyke-Young syndrome - a chronic macrocytic type, under Sidney Campbell Dyke, English pathologist, born 1886.
Hayem-Widal syndrome - acholuric haemolytic icterus with splenomegaly, under Georges Hayem, French physician and haematologist, 1841-1933.
Loutit’s syndrome - haemolytic jaundice, under John Freeman Loutit, British physician, born 1910.
Bibliography:
- M. Lederer:
A form of acute hemolytic anemia, probably of infectious origin.
American Journal of Medicine, New York, 1925, 170: 500-501.
- S. C. Dyke, F. Young:
Macrocytic hemolytic anemia associated with increased red cell fragility.
Lancet, London, 1938, II: 817-821.
- B. Dreyfus, J. Dausset, G. Vidal:
Étude clinique et hématologique de douze cas d’anémie hémolytique acquise avec anti corps.
Revue d'hématologie, 1951, 6: 349.
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