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Brooke's epithelioma
Also known as:
Ancell’s syndrome
Ancell-Spiegler cylindroma
Brooke's disease
Brooke's syndrome
Brooke's tumour
Brooke-Fordyce disease
Brooke-Fordyce trichoepithelioma
Brooke-Spiegler phakomatosis
Brooke-Spiegler syndrome
Spiegler's syndrome
Spiegler’s tumour
Associated persons:
Henry Ancell
Henry Ambrose Grundy Brooke
John Addison Fordyce
Eduard Spiegler
Description:
A usually benign skin disease most commonly occurring on the face, around the eyelids and on the scalp. The lesions form firm, flesh-coloured, translucent papules with slight surface telangiectasia; small lesions may coalesce to form a solid sheet tumor. They usually appear near puberty and become stationary after enlarging for several years. Regression and, rarely, malignant degeneration may occur. Etiology unknown. A familial disease transmitted as an autosomal dominant trait. The small scalp lesions have been called Ancell-Spiegler's tumours, the lesions affecting especially nasolabial area Brooke-Fordyce trichoepitheliomas.
Bibliography:
- H. Ancell:
History of a remarkable case of tumours developed on the head and face.
Medico-Chirurgical Transactions, London, 1842, 25: 227-247.
- H. A. G. Brooke:
Epithelioma adenoides cysticum.
British Journal of Dermatology, Oxford, 1892, 4: 269-286.
- J. A. Fordyce:
Multiple benign cystic epithelioma of the skin.
Journal of Cutaneous and Genitourinary Diseases, Chicago, 1892, 10: 459-473.
- E. Spiegler:
Über Endotheliome der Haut.
Archiv für Dermatologie und Syphilis, Berlin, 1899, 50: 163-176.
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