This syndrome consists of a malignant tumor, often metastasing to the liver, lungs, and bones. Present from birth or early infancy or onset in childhood, under age 10 years. Associated disorder may be abdominal and back pain, anorexia, debilitation, diarrhea or constipation, and various congenital malformations. Autosomal recessive inheritance. Both sexes affected. Symptoms and signs of the Hutchison syndrome are those of Parker’s syndrome, plus multiple bone metastases that confer on them a «moth eaten» aspect. Historical, no longer used term.
It was first described by Robert Virchow in 1864.
- R. Virchow:
Die krankhaften Geschwülste. 3 volumes, Berlin, 1863-1867.
- J. Abercrombie:
Multiple sarcomata of the cranial bones.
Transactions of the Pathological Society of London, 1880, 31: 216-223.
- R. W. Parker:
Diffuse sarcoma of the liver, probably congenital.
Transactions of the Pathological Society of London, 1880, 31: 290-293.
- W. Pepper:
A study of congenital sarcoma of the liver and suprarenal, with a report of a case.
American Journal of the Medical Sciences, Thorofare, N.J., 1901, 1221: 287-299.
- R. G. Hutchison:
On suprarenal sarcoma in children with metastases in the skull.
Quarterly Journal of Medicine, Oxford, 1907, I: 33-38.
- J. Smith:
Case of adrenal neuroblastoma. Lancet, London, 1932, 2: 1215-125.