- A dictionary of medical eponyms

Hoffmann's syndrome (Johann Hoffmann)

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Myopathy in hypothyroidism. Muscular symptom complex associated with a sustained acquired hypothyreosis. Muscle hypertrophy with fatigue, weakness, and slow and somewhat clumsy movements; associated with myxedema and pseudomyotonia. It is essentially a counterpart of the Kocher-Debré-Semélaigne syndrome that occurs in cretinism, but distinct from this by the presence of painful spasms and pseudomyotonia. Occurs in adults.


  • J. Hoffmann:
    Weiterer Beitrag zur Lehre von der Tetanie.
    Deutsche Zeitschrift für Nervenheilkunde, 1897, 9: 278-290.

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