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Johann Hoffmann
German neurologist, biorn 1857, Rheinhesse; died 1919, Heidelberg.
Associated eponyms:
Charcot-Marie-Tooth disease
A syndrome characterized by slowly progressive wasting and weakness of distal muscle of the arms and feet, the commonest disease within a group of conditions called Hereditary Motor and Sensory Neuropathies (HMSN).
Hoffman's phenomenon (Johann Hoffmann)
Excessive irritability of the sensory nerves to electrical or mechanical stimuli in tetany.
Hoffmann's reflex (Johann Hoffmann)
Finger reflex for hyper-reflexia.
Hoffmann's sign (Johann Hoffmann)
A phenomenon which is a electrophysiological sign of tetany.
Hoffmann's syndrome (Johann Hoffmann)
A muscular symptom complex associated with a sustained acquired hypothyreosis.
Werdnig-Hoffmann syndrome (Johann Hoffmann)
An infantile familial form of progressive spinal muscular atrophy resulting from degeneration of the anterior horn cells of the spinal cord.
Biography:
Johann Hoffmann was educated at Worms and graduated in medicine at Heidelberg. As an assistant in the department of neurology he became closely associated with professor Wilhelm Erb (1840-1921) whom he later replaced as head of the department. Late in life he was appointed full professor of neuropathology.
Bibliography:
- Über progressive neurotische Muskelatrophie.
Archiv für Psychiatrie und Nervenkrankheiten, 1889, 20: 660.
- Über chronische spinale Muskelatrophie im Kindesalter auf familiärer Basis.
Deutsche Zeitschrift für Nervenheilkunde 1893, 3: 427-470.
- Weitere Beiträge zur Lehre von der hereditären progressiven spinalen Muskelatrophie im Kindesalter nebst Bemerkungen über den fortschreitenden Muskelschwund im Allgemeinen.
Deutsche Zeitschrift für Nervenheilkunde, 1897, 10: 292-320.
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