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Froin's syndrome

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As commonly used the term «Froin’s syndrome» refers to the increased amount of exudative products - coagulation of spinal fluid - found in the spinal fluid below the level of a partial or complete block of the spinal canal. The cerebrospinal fluid, obtained by lumbar puncture, is yellow and the protein content is raised.

As originally described by Froin in 1903 the syndrome included xanthochromia and marked coagulation that he attributed to meningeal irritation. Max Nonne in 1910 emphasized that an excessive amount of globulin was present. Raven of Nonne’s clinic in 1912 attributed the high total protein to a spinal cord tumor.


  • G. Froin:
    Inflammations méningées avec réactions chromatique, fibrineuse et cytologique du liquide céphalo-rachidien.
    Gazette des hôpitaux, Paris, 1903, 76: 1005-1006.
  • M Nonne:
    Über das Vorkommen von starker Phase-I-Reaktion bei fehlender Lymphocytose bei 6 Fällen von Rückenmarkstumor.
    Deutsche Zeitschrift für Nervenheilkunde, 1910, 40: 161-167.

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