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Brandt's syndrome

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A zink deficiency syndrome in infants, characterized by acral dermatitis, alopecia, diarrhea, steatorrhea, and anal pustular eruptions on the face and around body orifices. Associated symptoms include failure to thrive, growth retardation, muscle wasting, irritability, depression, and photophobia. The syndrome is caused by the absence of the ligand essential for zing absorption, which is present in human but not cow milk. A similar disease picture may be seen in patients receiving artificial nutrition with low zink content. Untreated, the disease is usually lethal. Etiology unknown. Appear in both sexes; onset in early infancy. Autosomal recessive inheritance is probable.

First described by Brandt in 1936. The term Akrodermatitis enteropathica was introduced by Danbolt and Closs in 1942.


  • T. E. Brandt:
    Dermatitis in children with disturbances of the general conditions and the absorption of food elements.
    Acta dermato-venereologica, Stockholm, 1936, 17: 513-546.
  • N. C. G. Danbolt, K. Closs:
    Akrodermatitis enteropathica.
    Acta dermato-venereologica, Stockholm, 1942, 23: 127-169.

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