Kennedy's syndrome

Alternative eponyms

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Condition characterised by unilateral ipsilateral atrophy with contralateral papilloedema, central scotoma, and anosmia (absence of the sense of smell).

Description

Condition characterised by unilateral ipsilateral atrophy with contralateral papilloedema, central scotoma, and anosmia (absence of the sense of smell) usually due to a frontal lobe tumour or a meningioma of the optic nerve. There may be headache, dizziness, vertigo; occasionally, forceful vomiting, psychic changes (moria), memory loss.

The condition was first described by William Gowers in 1893. P. Schultz-Zehden described the symptoms in 1905, Paton in 1909. The first extensive and thorough account was made by Foster Kennedy in 1911. Later description by Wilhelm Uhthoff (1853-1927) in 1915.

Bibliography

  • P. Schultz-Zehden:
    Ein Beitrag zur Kenntnis der Genese einseitiger Stauungspapille.
    Klinische Monatsblätter für Augenheilkunde, Stuttgart, 1905, 43/II: 153.
  • F. Kennedy:
    Retrobulbar neuritis as an exact diagnostic sign of certain tumors and abscesses in the frontal lobe.
    American Journal of the Medical Sciences, Thorofare, N.J., 1911, 142: 355-368.
  • W. Uhthoff:
    Augensymptome bei Grosshirntumoren.
    Gräfe-Sämisch: Handbuch der Augenheilkunde, 1915. Volume I: 1143.

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