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Ahumada-del Castillo syndrome

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A disorder characterized by galactorrhea and amenorrhoea. Three types are reecognized:

Chiari-Frommel syndrome: persistent galactorrhoea and amenorrhea after giving birth.

Ahumada-Del Castillo syndrome: galactorrhoea-amenorrhoea not associated with pregnancy. There is oestrogen deficiency and decreased urinary gonadotropin levels.

Forbes-Albright syndrome: galactorrhea-amenorrhea caused by a chromophobe prolactin-producing adenoma of the pituitary


  • J. Chiari, Karl Braun, Joseph Späth:
    Klinik der Geburtshilfe und Gynäkologie. Erlangen, Enke, 1855.
  • R. Frommel:
    Über puerperale Atrophie des Uterus.
    Zeitschrift für Geburtshülfe und Frauenkrankheiten, Stuttgart, 1882, 7: 305-313.
  • J. C. Ahumada, E. B. del Castillo:
    Sobre in caso de galactorrea y amenorrea.
    Boletin de la Sociedad de obstetricia y ginecologia de Buenos Aires, 1932, 11: 64-72.
  • J. Argonz, E. B. Del Castillo:
    A syndrome characterized by estrogenic insufficiency, galactorrhea and decreased urinary gonadotropin.
    Journal of Clinical Endocrinology, Baltimore, 1953, 13: 79-87.
  • A. P. Forbes, P. H. Henneman, G. C. Griswold, F. Albright:
    Syndrome characterized by galactorrhea, amenorrhea and low urinary FSH. Comparison with acromegaly and normal lactation.
    Journal of Clinical Endocrinology and Metabolism, Baltimore, 1954, 14: 265-271.
  • S. S. C. Yen:
    Chronic anovulation.
    In S. S. C. Yean and R. B. Jaffe, editors: Reproductive endocrinology. Physiology, pathophysiology and clinical management. Philadelphia, Saunders, 1978, pp. 297-372.

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