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Elliott Lee Mancall

Born  1927-07-31
Died  2013-01-02

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Professor of Neurology at the Hahnemann Medical School in Philadelphi

Biography of Elliott Lee Mancall

Elliott Lee Mancall attended Trinity College, where he received a B.S. with honours in biological sciences in 1948, followed by an MD degree from the University of Pennsylvania in 1952. Mancall served a one year internship 1952-1953 at Hartford Hospital, Connecticut, and another year there as Assistant Resident in Surgery. He was awarded a Fulbright Scholarship and spent a year as Clinical Clerk at the National Hospital for Nervous Diseases, Queen Square, London. He did his residency in neurology at the Neurological Institute of New York, Columbia Presbyterian Medical Center (1955-1956), and a residency in neuropathology at Massachusetts General Hospital (1956-57). He then spent a year as Clinical and Research Fellow at that same hospital.

In 1958, Bernard J. Alpers, chair of neurology at Jefferson Medical College, recruited Dr. Mancall to Jefferson as an assistant professor of neurology. He became an associate professor in 1964. From 1965 to 1976 he was professor of medicine (neurology) at Hahnemann Medical College. In 1976 he became the founding chair of the new Department of Neurology at Hahnemann and remained in that capacity until 1994.

In 1995 Dr. Mancall moved back to Jefferson as professor of neurology, and from 1997 to 2003 was interim chair of the department. In 2005, he became Emeritus Professor of Neurology at Jefferson but continued to teach medical students and neurology residents. He took great pleasure in conducting Professor Rounds for neurology house staff, in the tradition of Dr. Raymond Adams and Dr. C. Miller Fisher, with whom he had trained at Massachusetts General.

Dr. Mancall was the recipient of numerous awards and was a valued member of a number of professional societies, including the American Neurological Association, the American Academy of Neurology (Fellow), the American Association of Neuropathologists.

Mancall served on the editorial board of several neurology journals.

Dr. Mancall's area of research included neurological complications of chronic alcoholism and malnutrition and neurological manifestations of systemic malignancy. Among his many scientific contributions, two discoveries have become classics in the neurology literature, with wide–ranging implications for the diagnosis and management of a variety of diseases.

With his colleagues, K. E. Åstrom and E. P. Richardson, he described progressive multifocal leukoencephalopathy (PML) as a complication of chronic lymphatic leukemia and Hodgkin's disease. PML was later found to be present in other diseases as well, including AIDS and immunodeficiency disorders.

With R. D. Adams and M. Victor, he described central pontine myelinolysis, a disease affecting the myelin sheath, the insulating cover of nerve cells, in the pons segment of the brain, induced by alcoholism, malnutrition and electrolyte imbalance. Recognition of these conditions has helped in the proper management of the afflicted patients and has saved many lives.

Information from a website by The Neurological Institute of New York Columbia University Medical Center, ”In Memoriam”,


Bernard Jacob Alpers and Elliott Lee Mancall:
•   Clinical Neurology. Philadelphia, F. A. Davis Company, 1971.

T.L. Munscat, E.L. Mancall, M.H. Brooke, G. Karpati, R.G. Miller, and S.P. Ringel:
•   Neuromuscular disease. A Program of the America Academy of Neurology, American Academy of  Neurology Multimedia Course. Includes: Duchenne/Becker Muscular Dystrophy; Facioscapulohumeral Dystrophy; Congenital Myotonic Dystrophy; Inflammatory disorders of muscle; Myasthenia Gravis; Motor Neuron Diseases; Periodic Paralyses and the Nondystrophic; Malignant Hperthermia; Toxic Myopathies; Mithochondrial Ciseases; and Metabolic Myopathies.

J.S. Schneider, D.P. Roeltgen, E.L. Mancall, J. Chapas-Crilly, D.S. Rothblat, and G.T. Tatarian:
•   Parkinson's disease Improved function with GM1 ganglioside treatment in a randomized placebo-controlled study. Neurology, Cleveland, Ohio, 1998, 50: 1630-1636.

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