Jaroslav Cervenka

Jaroslav Cervenka is presently (May 2000) professor at the Department or Oral Sciences, The University of Minnesota School of Dentistry, Dental research Institute. He was educated at the Faculty of General Medicine, Charles University, Prague Czechoslovakia, graduating MD i 1958. I 1968 he obtained PhD in Human genetics from the Czechoslovakia Academy of Sciences, Prague.

In 1982 he became diplomat in clinical cytogenetics from the American Board of Medical Genetics, and in 1993 was a Founding Fellow of the American College of Medical Genetics.

"My interests are in the genetics of developmental disorders, particularly the cleft lip and palate, and associated malformation syndromes. In cytogenetics, I am interested in cell hybridisation by electrical charge, cytogenetics of premalignant and DNA repair disorders."

Recently (May 2000), he and his colleagues developed a way to use electrical current dielectrophoresis for cell fusion. A variety of cell lines are used and methods are being standardized. They also have been able to induce premature chromosome condensation (PCC) by electrofusion of mitotic and interphase cells. This method could be used in chromosomal analysis of non-dividing somatic cells, and in mutagenesis studies.

This information was taken from his homepage at The University of Minnesota School of Dentistry, Dental research Institute.

According to one of our users, Mike Arnold, the term dielectrophoresis was coined by Herbert Ackland Pohl (1916-1986), formerly Professer at Oklahoma State University. He published a monograph on this in 1978.

• J. Cervenka and Lucien Koulischer, edited by Robert J. Gorlin:
  Chromosomes in human cancer.
  Springfield, Illinois, Thomas, 1973. 203 pages and 24 illustrations.
• Garry, F.V., Griffith, J., Danzl, J.J., Nelson, R.L., Wharton, E.B., Krueger, L.A., and Cervenka, J:
  Human genotoxicity: pesticide applicators and phosphine.
  Science, Washington, 1989, 246:251-255.
• L. O. Langer, Jr., J. Cervenka, and M. Camargo:
  A severe autosomal recessive acromesomelic dysplasia, the Hunter-Thompson type, and comparison with the Grebe type.
  Human Gentics, Berlin, 1989, 81: 323-328.
• Oguro, J. Cervenka, and K. Horii:
  Effect of sodium fluoride on human diploid cells in tissue culture: c chromosomal ploidy and breakage.
  Pharmacology and Toxicology, Copenhagen, 1990, 67: 411-414.
• K. Kurvink, and J. Cervenka:
  Acrocentric prophasing in bromodeoxyuridine incorporated chromosomes.
  Cancer Genetics and Cytogenetics, 1990, 50: 265-271.
• J. Siroky, and J. Cervenka:
  Hybridization frequencies of different mammalian celltypes by electrofusion.
  General Physiology and Biophysics, Bratislava, 1990, 9: 489-505.
• S. Lobo, J. Cervenka, A. London, and M. E. Pierpont:
  Interstitial deletion of 10 q: Clinical features and literature review.
  American Journal of Medical Genetics, New York, 1992, 43: 701-703.
• V. F. Garry, J. Cervenka, et al:
  Chromosome rearrangements in fumigant appliers: Possible relationship to non-Hodgkin's lymphoma risk.
  Cancer Epidemiology, Biomarkers and Prevention, 1992, 1: 287-291.
• Oguro, J. Cervenka, and K. Horii:
  Effect of sodium fluoride on chromosome ploidy and breaks in cultured human diploid cells (IMR-90): An evaluation of continuous and short time treatment.
  Pharmacology and Toxicology, Copenhagen, 1995, 76: 292-296.
• M. Camargo, and J. Cervenka, J. R-banding:
  An Internatl. System for Human Cytogenetic Nomenclature (ISCN).
  F. Mitelman, (editor). S. Karger, Basel, 1995.
• J. T. Thomas, K. Lin, M. Nandedkar, W. McBride, M. Camargo, J. Cervenka, and F. P. Luyte:
  A human chondrodysplasia due to a mutation in TGF-beta superfamily member.
  Nature Genetics, 1996, 12: 315-317.
• Herbert Ackland Pohl:
  Dielectrophoresis - the behavior of neutral matter in nonuniform electric fields.
  Cambridge University Press. Cambridge, 1978.
  Pohl first published on dielectrophoresis in the 1950’s.