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Frank Burr Mallory
American pathologist, born November 12, 1862, Cleveland, Ohio; died 1941.
Associated eponyms:
Mallory's bodies I
Bodies in the lymph spaces and epidermal cells in scarlet fever.
Mallory's bodies II
Alcoholic hyaline bodies.
Mallory's collagen stain
One of a number of staining methods using phosphomolybdic or phosphotungstic acid with an acid stain, such as aniline blue, or with haematoxylin for connective tissue staining.
Mallory's hyaline
Mallory bodies are aggregates of intermediate filaments found in the hepatocytes of patients with impaired hepatic cellular structure. Because of the glassy eosinophilic appearance of these bodies.
Mallory's iodine stain
Amyloid appears red-brown after Gram's iodine, then violet and blue after flooding with dilute sulfuric acid.
Mallory's phloxine stain
A technique based on retention of phloxine by hyaline after overstaining and then decolorizing with lithium carbonate, used in combination with alum haematoxylin to give nuclear staining.
Mallory's phosphotungstic acid haematoxylin stain
A stain with broad application in cytology and histology.
Mallory's stain
Method of staining connective tissue.
Mallory's stain for actinomyces
A stain for actinomyces using alum haematoxylin, followed by eosin.
Mallory's trichrome stain
A method especially suitable for studying connective tissue.
Mosse-Marchand-Mallory cirrhosis
A usually fatal form of cirrhosis of the liver.
Biography:
Frank Burr Mallory graduated M.D. from Harvard Medical School in 1890. The following year he came to the Boston City Hospital as an assistant under William Thomas Councilman (1854-1933). He subsequently received trained in histology and pathology with Hans Chiari (1851-1916) in Prague and Ernst Ziegler (1849-1905) in Freiburg.
After his return to the U.S.A., Mallory made a swift career at Harvard University, becoming instructor in 1894, 1896 assistant professor, and in 1901 associate professor of pathology. From 1928 to 1932 he was professor of pathology at the Harvard Medical School. His hospital affiliation was as a pathologist at the Boston City Hospital, where a new pathology building was named after him the year after his death.
He was the father of G. Kenneth Mallory (1900–) and publisher of The American Journal of Pathology.
«I never found that arguing did much good. If my facts were not convincing I went to work to find others which were.»
Advice to a colleague engaged in a scientific argument.
Bibliography:
- Pathological Technique : a practical manual for workers in pathological histology and bacteriology : including directions for the performance of autopsies and for clinical diagnosis by laboratory methods.
With James Homer Wright. Philadelphia and London, 1897; 8th edition, 1924.
This book was pre-eminent in the English-speaking world and a major force in improving staining techniques and stain standardisation.
- The principles of pathological histology. Philadelphia and London, 1914.
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