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Mitchell's syndrome I

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An idiopathic paroxysmal vasodilation of peripheral vasculature marked by sudden onset of burning pain in the hands and feet, diminution of temperature sense, and occasional glossalgia and feeding difficulty. The fingers and toes usually become red with thickened terminal phalanges and nail beds, and superficial veins are grossly engorged. Although sensitivity to temperature changes are diminished, cold acts as a pain depressor and heat as a stimulator. Most pronounced in the toes. Occurs equally in both sexes. Onset usually over middle age. Etiology unknown. Autosomal dominant inheritance reported in some families.


  • S. Weir Mitchell:
    Clinical Lecture On Certain Painful Affections of the Feet.
    Philadelphia Medical Times, 1872, 3: 81-82, 113-115.
  • C. Gerhardt:
    Über Erythromelalgie.
    Berliner klinische Wochenschrift, 1892, 29: 1125.

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