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Hanot-Rössle syndrome

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Historical, no longer commonly used term for a form of secondary biliary cirrhosis. Nonobstructive extrahepatic cholangitis with obstructive intrahepatic cholangitis, and cholestasis due to duodenal dyskinesia infection. A syndrome characterized by fever, jaundice, generalized lymphadenopathy, hepatomegaly, and moderate splenomegaly, skin pigmentation; xanthoma. Prevalent in middle-aged females; insidious onset.

Hanot first described the «cirrhose biliaire primitive in 1875. Robert Rössle in 1930 demonstrated that the biliary obstruction is really intrahepatical localised, and from the general concept elaborated the particulars of this syndrome. Hanot’s cirrhosis and the Rössle syndrome are variants of the same disturbance.


  • V. C. Hanot:
    Étude sur une forme de cirrhose hypertrophique du foie (cirrhose hypertrophique avec ictère chronique).
    Thèse de Paris, 1875, Nr. 465. Published in book form, Paris, 1876.
  • R. Rössle:
    Entzündungen der Leber.
    In: Friedrich Henke (1868-1943) and Otto Lubarsch, publishers: Handbuch der speziellen pathologischen Antomie und Histologie.
    Volume 5. 1. part, p 243. Berlin, 1930.
  • G. Albot, M. Kopandji:
    La cholangiolite obstructive au cour des cholangites diffuses non oblitérantes ou maladie de Hanot-Rössle.
    Semaine des hôpitaux de Paris, 1962, 38: 3213-3231.

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