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Hanot-Kiener syndrome

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Historic term for a diffuse chronic mesenchymatous hepatitis. Characterized by perilobal cholestasis with hepatitis due to obstruction of the bile ducts by giant peripheral lymphoid follicles enclosing the source of the Hering canals and the terminal portion of the hepatic ducts. It is probably what is now diagnosed as «chronic persistent hepatitis».

Hanot first described the ”cirrhose biliaire primitive” in 1875; from this general concept Kiener worked out this particular subform.


  • Guy Albot, J. Lunel:
    L'hépatite mésenchymateuse diffuse avec lymphomatose nodulaire de Hanot et Kiener.
    Path Biol, Paris, 1961; 9: 239-250.

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