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Verner-Morrison syndrome

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A syndrome of profuse intermittent diarrhoea, hypokalaemia, dehydration and achlorhydria, often due to an excessive secretion of vasoactive intestinal peptide from a vipoma especially of the pancreas. Onset from 2nd to 6th decades, predominant in 5th decade. In acute stages, cholera-like diarrhea, abdominal pain, nausea, and vomiting. In quiescent state, mushy stools and weight loss. Generalized weakness progressing to paralysis and then to stupor. Duration of symptoms from months to years. Spontaneous remission during pregnancy.


    M. P. Moldawer, G. L Nardi, J. W. Raker:
    Concomitance of multiple adenomas of the parathyroids and pancreatic islets with tumor of the the pituitary: a ssyndrome with familial incidence.
    American Journal of the Medical Sciences, Thorofare, N.J, 1954, 228: 190-206.
  • W. M. Priest, M. Alexander:
    Islet cell tumor of the pancreas with peptic ulceration, diarrhoea, and hypocalemia.
    The Lancet, London, 1957, II: 1145-1147.
  • J. V. Verner, A. B. Morrison:
    Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia.
    American Journal of Medicine, New York, January 27, 1958, 25 (4): 374-380.
  • W. C. Chasm, I. E. T hompsosis, C. O. Patenoa:
    Pancreatic islet tumor with severe diarrhea.
    American Journal of Medicine, 1960, 29: 529-533.
  • J. V. Verner and A. B. Morrison:
    Endocrine pancreatic islet disease with diarrhea: report of a case due to diffuse hyperplasia of nonbeta islet tissue with a review of 54 additional cases.
    Archives of Internal Medicine, Chicgo, 1974, 133: 492-500.
  • S. R. Bloom, I. M. Polak, A. G. E. Pearse:
    Vasoactive intestinal peptide and watery diarrhea syndrome.
    The Lancet, 1973, 2: 14-16.

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