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Jarcho-Levin syndrome

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A syndrome of severe malformation of the spinal column and thoracic cage. Death from respiratory insufficiency occurs in infancy. Occurs in two types. Type 1 occurs most commonly in children of Puerto Rican ancestry and is inherited as an autosomal recessive. trait. Type 2 is transmitted as an autosomal dominant trait and occurs mainly in white children, usually with nearly normal longevity.

We thank Joseph Constantin, France, for information submitted.


  • S. Jarcho, P. M. Levin:
    Hereditary malformation of the vertebral bodies.
    Bulletin of the Johns Hopkins Hospital, Baltimore, 1938, 62: 216-229.
  • N. W. Lavy, C. G. Palmer, A. D. Merritt:
    A syndrome of bizarre vertebral anomalies.
    Journal of Pediatrics, St. Louis, 1966, 69: 1121-1125.
  • A. PĂ©rez-Comas, J. M. Garcia-Castro:
    Occipito-facial-cervico-thoracic-abdomino-digital dysplasia: Jarcho-Levin syndrome of vertebral anomalies.
    Journal of Pediatrics, St. Louis, 1974, 85: 388-391.

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