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Crabtree's effect

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    A metabolic effect typical of tumour tissue: inhibition of cellular respiration by high concentration of glucose.


    • H. G. Crabtree:
      Observations on the carbohydrate metabolism of tumors.
      The Biochemical Journal, London, 1929, 23: 536, 545.
      Crabtree noted that "the glycolytic activity of tumour cells exerts a checking effect on their respiration."

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