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Sampson's theory

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A theory for the origin of endometriomas. Sampson proposed that endometriosis is a process produced by the escape of endometrial tissue that escapes retrograde through the fallopian tubes into the pelvis. This then leads to secondary reactions of inflammation, repair, and scar formation.


  • J. A. Sampson:
    Perforating hemorrhagic (chocolate) cysts of the ovary. Their importance and especially their relation to pelvic adenomas or endometrial type (“adenomyoma” of the uterus, rectovaginal septum, sigmoid, etc.).
    Archives of Surgery, Chicago, 1921; 3: 245-323.

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