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Holtermüller-Wiedemann syndrome

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A rare congenital syndrome in which hydrocephalus resulting from intrauterine craniosynostosis gives the skull a flattened, cloverleaf like configuration. The first exact description was probably made by Willem Vrolik (1801-1863) in 1840; subsequent numerous descriptions. Thorough work over of the deformity by Holtermüller and Wiedemann in 1960.


  • W. Vrolik:
    Handbuch der ziektekundige ontleedkunde. 2 parts, Amsterdam, 1840-1842.
    Also known under the title of De vrucht van den mensch e van den zoogdieren afgebeeld en beschreeven in hare regelmatige en onregelmatige ontwikkeling.
  • K. Holtermüller, H-R. Wiedemann:
    Medizinische Monatsschrift, Stuttgart, 1960, 14: 439-446.
  • D. S. Comings:
    The Kleeblattschädel syndrome – a grotesque form of hydrocephalus.
    The Journal of Pediatrics, St. Louis, 1965, 67: 126-129.

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