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Pemberton's sign

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The development of facial plethora, cyanosis and distension of neck veins with raising both arms simultaneously. A positive test indicates thoracic inlet obstruction, originally described in patients with retrosternal goitre but may also be seen in lung carcinoma, lymphomas, thymomas, dermoid cysts or aortic aneurysms.

We thank Kwan S. Lee for information submitted.


  • H. S. Pemberton:
    Sign of submerged goitre. The Lancet, London, 1946, 251: 509.

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