- A dictionary of medical eponyms

Unna-Thost syndrome

Related people

A rare hereditary skin disease with variable involvement of the palms and soles. Typically, the lesions are thick, horny, hard, yellowish plaques with waxy smooth surfaces, although in some cases they may be pitted and verrucous, surrounded by erythematous halos. Occasionally associated corneal opacities, pilitorti, sensorineural hearing loss, hypohidrosis, dental abnormalities. Inheritance is autosomal dominant. According to one author, it also occurs in an acquired form preceding hyperhidrosis

We thank Andre Trombeta for information submitted.


  • A. Thost:
    Über erbliche Ichtyosis palmaris et plantaris cornea. Dissertation, Heidelberg, 1880.
  • P. G. Unna:
    Über das Keratoma palmare et plantare hereditarium.
    Vierteljahrsschrift für Dermatologie und Syphilis, Wien, 1883, 15: 231.
  • A. Brauer:
    Über eine besondere Form des hereditären Keratoms (Keratoma dissipatum hereditarium palmare et plantare).
    Archiv für Dermatologie und Syphilis, Berlin, 1912, 114: 211-236.
  • S. R. Brünauer:
    Zur Vererbung des Keratoms hereditarium palmare et plantare.
    Acta dermato-venereologica, Stockholm, 1923-1924, 4: 489-503.
  • A. Greither:
    Keratosis extremitatum hereditaria progrediens mit dominanten Erbgang.
    Der Hautarzt, Berlin, 1952, 3: 198-203.
  • H. W. Siemens and Winkler:
    Über regelmässige Dominanz und andere Vererbungsmodi bei Keratosis plantaris et palmaris (Verhornung der Hand- und Fussflächen). Sitzungsberichte der Gesellschaft für Morphologie und Physiologie in München, 1924 (1925), 36: 45-47.
  • S. R. Brünauer:
    Zur Symptomatologie und Histologie der kongenitalen Dyskeratosen.
    Dermatologische Zeitschrift, Basel, 1925, 42: 6-26.
  • H. Fuhs:
    Keratoma palmare et plantare. Zentralblatt für Haut- und Geschlechtskrankheiten sowie deren Grenzgebiete, Berlin, 1933, 46: 292.

What is an eponym?

An eponym is a word derived from the name of a person, whether real or fictional. A medical eponym is thus any word related to medicine, whose name is derived from a person.

What is Whonamedit?

Whonamedit.com is a biographical dictionary of medical eponyms. It is our ambition to present a complete survey of all medical phenomena named for a person, with a biography of that person.


Whonamedit? does not give medical advice.
This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor.