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Kimmelstiel-Wilson syndrome (Clifford Wilson)

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A kidney disease characterized by hypertension, renal lesions, glomerulonephrosis, oedema, and retinopathy. Arteriosclerosis of the renal artery is a frequent complication. Proteinuria occurs. It develops in about 20 to 25 percent of patients, in whom diabetes mellitus has been present for several years, usually beginning about 15 years after onset of diabetes. Most patients are between 50 and 70 years old. The disease has a progressive course and death usually occurs within two years after recognition of the renal lesion. More frequent in women than in men. The nodular lesions have been known as Kimmelstiel-Wilson lesions.

Paul Herbert Kimmelstiel: «We have learned that this correlation is much closer to non-specific glomerular changes which were carefully excluded in the original presentation. The term Kimmelstiel-Wilson syndrome is, therefore, not justified. »


  • P. Kimmelstiel, C. Wilson:
    Benign and malignant hypertension and nephrosclerosis. A clinical and pathological study.
    American Journal of Pathology, Philadelphia 1936, 12: 45-48.
  • P. H. Kimmelstiel, C. Wilson:
    Intercapillary lesions in the glomeruli of the kidney.
    American Journal of Pathology, Philadelphia, 1936, 12: 82-97.

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