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Waldenström's hyperglobulinaemia

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An autoimmune, chronic blood disease marked by relapsing, nonthrombocytopenic purpuric eruptions over the lower limbs, leaving brown pigmentation, high erythrocyte sedimentation rate, marked increase in the serum gamma globulin level, and mild anaemia. Moderate hepatosplenomegaly may be associated. This and the Bern-Kunkel syndromes are similar in many respects.

The condition runs a relatively benign, protracted course and may occur at any age. Females are more often affected.


  • J. Waldenström:
    Zwei interessante Syndrome mit Hyperglobulinämie. (Purpura hyperglobulinaemica und Makroglobulinämie).
    Schweizerische medizinische Wochenschrift, Basel, 1948, 78: 927-928.

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