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Stein-Leventhal syndrome

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A condition characterized by multiple ovarian cysts, obesity, hirsutism, menstrual abnormities, amenorrhoea or oligomenorrhoea, infertility and sometimes hyperprolactinaemia and virilization. Onset after puberty or in late teenage years. Autosomal dominant inheritance reported in some families. In familial form, males abnormally hairy.

In 1928 the Russian gynaecologist S. K. Lesnoy described cystic ovaries, but not the whole syndrome.

We thank Leonid P. Churilov and Dr. Akaki Bakradze for information submitted.


  • S. K. Lesnoy:
    Chastichnaja rezekcija jaichnikov pri olygomenoree i amenoree.
    Akusherstvo i Ginekologiia, 1928, No 2: 184-191 I. F. Stein, M. L. Leventhal:
    Amenorrhea associated with bilateral polycystic ovaries.
    American Journal of Obstetrics and Gynecology, St. Louis, 1935, 29: 181-191.
  • I. F. Stein;:
    The Stein-Leventhal syndrome. A curable form of sterility.
    The New England Journal of Medicine, Boston, 1958, 259: 420-423.
  • H. E. Cooper, W. N. Spellacy, K. A. Prem, W. D. Cohen:
    Hereditary factors in the Stein Leventhal syndrome.
    American Journal of Obstetrics and Gynecology, St. Louis, 1968, 100: 371–387.
  • J. R. Givens, W. L. Wisser, S. A Coleman, R. S. Wilroy, R. N. Andersen, S. A. Fish, B. S. Watson:
    Familial ovarian hyperthecosis: a study of two families.
    American Journal of Obstetrics and Gynecology, St. Louis, 1971, 110: 959-972.
  • A. Borghi, M. Maiello, G. Giusti:
    Stein-Leventhal syndrome in sisters. The possible role of genetic factors in the "polycystic ovary syndrome".
    Acta geneticae medicae et gemellologiae, Rome, 1972, 21: 79-73.
  • F. P. Mandel, R, J. Chang, B. Dupont, M. S. Pollack, L. S. Levine, M. I. New, J. Lu, H. L. Judd:
    HLA genotyping in family members and patients with familial polycystic ovarian disease.
    The Journal of Clinical Endocrinology and Metabolism, 1983, 56: 862-864.
  • J. R. Givens:
    Familial polycystic ovarian disease.
    Endocrinology and Metabolism Clinics of North America, Philadelphia, 1988, 17: 771-783.

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