- A dictionary of medical eponyms

Sakurai-Lisch nodules

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An iris lesion typically seen in type I neurofibromatosis. The nodule may be a neurofibroma arising from peripheral schwannian elements or melanocytic hamartomas of neural crest origin.

For more details about the elucidation of this disease, see the biography of Karl Lisch, by Arun D. Singh.


  • S. Snell, E. Treacher Collins:
    Plexiform neuroma (elephantiasis neuromatosis) of temporal region, orbit, eyelid and eyeball. Notes of three cases.
    Transactions of the Ophthalmological Societies of the United Kingdom, London, 1903, 23: 157-177.
    Probably the first cases reported of true Lisch' nodules.
  • E. Fuchs:
    Naevus pigmentosus und Naevus vasculosus der Iris.
    Albrecht von Graefes Archiv fur Ophthalmologie, 1913, 86: 155-169.
  • I. Goldstein, D. Wexler:
    Melanosis uveae and melanoma of the iris in neurofibromatosis (Recklinghausen).
    Archives of Ophthalmology, Chicago, 1930, 3: 288-296.
  • J. Van der Hoeve:
    The Doyne Memorial Lecture. Eye Symptoms in phakomatoses.
    Transactions of the Ophthalmological Societies of the United Kingdom, London, 1932, 52: 380-401.
  • T. Sakurai:
    Multiple neurofibroma patient showing multiple flecks on the anterior surface of the iris.
    Acta Societatis ophthalmologicae Japonicae, Tokyo, 1935, 39:87-93.
  • K. Lisch:
    Ueber Beteiligung der Augen, insbesondere das Vorkommen von Irisknotchen bei der Neurofibromatose (Recklinghausen).
    Zeitschrift für Augenheilkunde, Basel, 1937, 93: 137-143.
  • K. Lisch:
    Die vier Phakomatosen.
    Münchener medizinische Wochenschrift, München, 1942, 25: 564-566.
  • Richard A. Lewis, Vincent M Riccardi:
    Von Recklinghausen neurofibromatosis: Incidence of iris hamartomata.
    Ophthalmology, Philadelphia, 1981, 88: 348-354.

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