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Lambert-Eaton-Rooke syndrome

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A myasthenic syndrome usually associated with an underlying disease, particularly a bronchial carcinoma, characterized by weakness and fatigability in the proximal muscles of the limbs. There is sensory neuropathy, weak or absent tendon reflexes, impotence, difficulties in micturition, dry mouth and constipation. Onset in middle life. It is more common in men than in women, most common in males over the age of 40 years. In 40 percent of cases no cause is found and the disease is called idiopathic Lambert-Eaton myasthenic syndrome.


  • E. H. Lambert, L. M. Eaton, E. D. Rooke:
    Defect of neuromuscular conduction associated with malignant neoplasms.
    American Journal of Physiology, Bethesda, Maryland, 1956, 187: 612-613.

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