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Cogan-Reese disease

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A syndrome characterized by a matted or smudged appearance to the surface of the iris, unilateral glaucoma in the eyes with multiple peripheral anterior synechiae, multiple nodules of the iris, and ectopic Descemet's membrane. Associated disorders may include corneal oedema, stromal iris atrophy, iris pigment epithelial atrophy, ectropion uveae, and ectopic pupil. Secondary glaucoma may lead to vision loss. This disorder most frequently appears in young and middle-aged females, usually affecting only one eye and developing slowly over time.

Cogan-Reese syndrome is a subset of the larger disease category iridocorneal endothelial syndrome, which is characterized by abnormal proliferation of the corneal endothelium over the cornea, iridocorneal angle, and onto the surface of the iris. The condition is extremely rare.


  • D. G. Cogan, A. B. Reese:
    A syndrome of iris nodules, ectopic Descemets membrane, and unilateral glaucoma.
    Documenta Ophtalmologica, Den Haag, 1969, 26: 424-433.

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